Imikhiqizo

I-67567-26-4 iyinhlanganisela eye yaheha ukunakwa okuningi kumakhemikhali nezinkambu ezihlobene. Ngenxa yokuntuleka kolwazi oluningiliziwe, kucatshangelwa emithethweni evamile yezinto zamakhemikhali ukuthi ingase ibe nesakhiwo samangqamuzana akhethekile futhi ingase ibe namabhondi amakhemikhali athile akhethekile noma amaqembu asebenzayo, okuyinikeza umsebenzi wamakhemikhali oyingqayizivele futhi cishe izodlala indima ebalulekile ekuhlanganiseni izinto ezibonakalayo, ukukhiqizwa kwamakhemikhali, nokucwaninga kwesayensi.

I-Pharmaceutical Intermediate 1180132-17-5, igama lekhemikhali 5-((4-ethylpiperazine-1-yl)methyl)pyridin-2-amine, iwukhiye osetshenziswayo onamathemba okusebenza abanzi emikhakheni yezokwelapha nemboni yamakhemikhali. Lokhu okuphakathi kwemithi kunokwakheka kwamakhemikhali okuyingqayizivele, ifomula yamangqamuzana C12H20N4, nesisindo samangqamuzana esingaba ngu-220.31. Inombolo yayo ye-CAS ithi 1180132-17-5, imvamisa isesimweni esiqinile esimhlophe noma esimhlophe, futhi ubumsulwa bomkhiqizo onikezwe inkampani yethu buphezulu obufinyelela ku-99%, okuqinisekisa ukusetshenziswa kwawo ngempumelelo ekuhlanganiseni kwemithi.

Njengempahla ebalulekile yokwenziwa kwemithi, i-1180132-17-5 idlala indima ebalulekile ekuhlanganisweni kwezidakamizwa ezilwa nomdlavuza njenge-Abemaciclib. I-Abemaciclib iyi-CDK4/6 inhibitor esebenza kahle kakhulu futhi isetshenziswa kabanzi ekwelapheni umdlavuza webele, ikakhulukazi ezigulini ezinomdlavuza webele we-hormone receptor-positive kanye ne-HER2-negative. Ngokulawula okunembile kwenqubo yokuhlanganisa, abaxhumanisi bethu bezemithi banikeza isiqiniseko sekhwalithi esizinzile nesithembekile sokukhiqizwa kwemithi efana ne-Abemaciclib.

I-Pharmaceutical Intermediate 1231930-33-8, igama lekhemikhali 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole, iwukhiye wezinto zokwenziwa zemithi futhi isetshenziswa kabanzi ocwaningweni lwezidakamizwa nasekuthuthukisweni nasekukhiqizeni.

I-1231930-37-2 iyinhlanganisela eye yavela emkhakheni wobunjiniyela bamakhemikhali nocwaningo lwesayensi. Ngenxa yokuntuleka kolwazi oluningiliziwe, kucatshangelwa ngokusekelwe ezimisweni zamakhemikhali ukuthi ukwakheka kwayo okuyingqayizivele kwamangqamuzana kungase kuqukathe amaqembu athile asebenzayo asebenzayo, okungase kuyenze ibambe iqhaza elibalulekile ekuphenduleni kwamakhemikhali amaningi futhi kulindeleke ukuthi ibambe iqhaza elibalulekile ekusungulweni kwezinto ezibonakalayo, ukuhlanganiswa kwamakhemikhali, njll.

I-1231930-42-9 iyinhlanganisela eye yaheha ukunaka okukhulu ocwaningweni lwamakhemikhali nokukhiqizwa kwezimboni. Nakuba ulwazi oluningiliziwe lungekho njengamanje, olusekelwe ezicini ezijwayelekile zezinto zamakhemikhali, kucatshangelwa ukuthi ukwakheka kwayo kwamangqamuzana kungase kuqukathe inhlanganisela eyingqayizivele yamaqembu asebenzayo, okuyenza ibonise umsebenzi othile ekuphenduleni kwamakhemikhali okuhlukahlukene futhi cishe izodlala indima ebalulekile emikhakheni yokuthuthukiswa kwezinto ezibonakalayo, ukuhlanganiswa kwemithi ephakathi kwemithi, kanye namakhemikhali amahle.

I-29274-22-4 iyinhlanganisela yezinto eziphilayo enenani elibalulekile lokusetshenziswa, futhi igama layo lekhemikhali limiswe okwesikhashana njengokuthi [igama lekhemikhali elisebenzayo]. Isakhiwo sayo samangqamuzana siqukethe inhlanganisela ethile yamaqembu asebenzayo. Lesi sakhiwo esiyingqayizivele siwunikeza umsebenzi okhethekile wamakhemikhali kanye nezakhiwo zomzimba. Ibonise amandla amakhulu ezimbonini eziningi, ikakhulukazi emkhakheni wamakhemikhali amahle kanye nokuguqulwa kwezinto ezibonakalayo, futhi ivame ukusetshenziswa njengendlela yokusabela okubalulekile okuphakathi.

I-29274-24-6 iyinhlanganisela enenani eliyingqayizivele embonini yamakhemikhali. Nakuba ulwazi lwayo lwangempela lungekho okwamanje, kusukela ekuhlaziyweni kwezakhiwo zamakhemikhali ezivamile, ingaba nokuhlelwa okukhethekile kwe-athomu kanye namaqembu asebenzayo, okukunikeza indima engenakuthathelwa indawo ekuphenduleni okuthile kwamakhemikhali futhi kulindeleke ukuthi ibe yingqikithi yezinto ezibonakalayo zokulungiswa kwezinto ezisebenza kahle kakhulu kanye namakhemikhali anomphumela okhethekile.

Emkhakheni wamakhemikhali emithi, umkhiqizo ophakathi obalulekile udonse ukunaka okukhulu, okuyi-1218935-60-4, eyaziwa nangokuthi (R) -2-(2,5-difluorophenyl)pyrrolidine hydrochloride. Ukuvela kwalo mkhiqizo kunikeza izinto zokusetshenziswa ezibalulekile zokwenziwa kwemithi futhi kukhuthaza ukuthuthukiswa kwemboni yezemithi.

I-1363380-51-1 iyinhlanganisela eye yaheha ukunaka okukhulu embonini yamakhemikhali nezinkambu ezihlobene. Nakuba kukhona ukuntuleka kolwazi oluningiliziwe, kucatshangelwa emithethweni evamile yocwaningo lwamakhemikhali ukuthi ingase ibe nesakhiwo samangqamuzana esiyingqayizivele nomsebenzi okhethekile wamakhemikhali, futhi kungenzeka kakhulu ibe into eyinhloko ekuthuthukisweni kwezinto ezintsha, ama-catalysts asebenza kahle kakhulu namakhemikhali amasha, okubonisa amathemba okusebenza okubanzi ezimbonini eziningi.

I-1919868-77-1 iyinhlanganisela engaqondakali enenani elingaba khona emikhakheni eminingi. Nakuba ulwazi lulinganiselwe okwamanje, ngokwemithetho evamile yocwaningo lwamakhemikhali, kucatshangwa ukuthi lunokwakheka kwamakhemikhali okuhlukile futhi lungaba namaqembu asebenzayo akhethekile, alunikeza indima ebalulekile ekuphenduleni kwamakhemikhali okuthile. Kulindeleke ukuthi ibambe iqhaza elibalulekile emikhakheni yezinto zokwakha, amandla, imithi, njll., futhi ilethe amathuba okuqamba izinto ezintsha ezimbonini ezihlobene.

I-13721-01-2 iyinhlanganisela engene kancane kancane emkhakheni wocwaningo emkhakheni wamakhemikhali. Ngenxa yokuntuleka kolwazi oluningiliziwe njengamanje, kucatshangelwa ngokusekelwe ezicini ezijwayelekile zezinto zamakhemikhali ukuthi ukwakheka kwayo kwamangqamuzana kungase kuhluke, mhlawumbe ngenhlanganisela ekhethekile yamabhondi amakhemikhali noma ukuhlelwa kweqembu elisebenzayo, elinikeza umsebenzi oyingqayizivele ekuphenduleni kwamakhemikhali futhi kulindeleke ukuthi libambe iqhaza elibalulekile emikhakheni eminingi njengocwaningo nokuthuthukiswa kwezinto ezibonakalayo, amakhemikhali amahle kanye ne-biopharmaceuticals.

I-873055-58-4 iyinhlanganisela enenani lokucwaninga elingase libe khona emkhakheni wamakhemikhali. Ngenxa yokuntuleka kolwazi oluningiliziwe njengamanje, kucatshangelwa ngokusekelwe emithethweni evamile yezinto zamakhemikhali ukuthi ukwakheka kwawo kwamangqamuzana kungase kuhluke, futhi kungase kube nokuhlelwa okukhethekile kwamabhondi amakhemikhali noma inhlanganisela yamaqembu asebenzayo, okukunikeza umsebenzi oyingqayizivele ekuphenduleni kwamakhemikhali futhi okulindeleke ukuba kudlale indima ebalulekile emikhakheni eminingi efana nesayensi yezinto zokwakha, ukuhlanganiswa kwamakhemikhali, kanye ne-biomedicine.

I-1262198-07-1 iyinto ebalulekile yamakhemikhali ephilayo, esetshenziswa kabanzi ekuhlanganiseni izinto ezihlukahlukene zamakhemikhali. Ivamise ukunikezwa ngokuhlanzeka okuphezulu, okufana nama-98% nangaphezulu, ukuze kuhlangatshezwane nezidingo zocwaningo lwesayensi kanye nezicelo zokwenziwa ezisezingeni eliphezulu. Inokuqina okuhle kwamakhemikhali ngaphansi kwezinga lokushisa elivamile kanye nokucindezela kanye nezimo ezivamile zokugcina. Ngenxa yobukhona be-bromine kwindandatho ye-benzene Ama-Athomu, ama-athomu e-fluorine namaqembu e-amino ayenza ibe nokuphinda kusebenze okuhlukile futhi ingabamba iqhaza ezinhlobonhlobo zokusabela kwe-organic synthesis, njenge-nucleophilic substitution, i-ligand reaction, njll. Iyingxenye ebalulekile yokuhlanganiswa kwezinhlobonhlobo zezidakamizwa, izibulala-zinambuzane namanye amakhemikhali amahle.

1. I-molecular formula ye-1008138-73-5 yi-C9H12N2O2. Iyimpushana emhlophe kuya kokumhlophe. Njengengxenye ebalulekile ye-organic, inokubili imisebenzi yeqembu le-amino ne-ester futhi isetshenziswa kabanzi emkhakheni wezokwelapha, izibulala-zinambuzane kanye nesayensi yezinto. Inekhwalithi ethembekile nokuhlanzeka okuphezulu.

2. Ikhwalithi ephezulu ye-5-amino-6-methylnicotinate ethyl ester inezinto zamakhemikhali eziyingqayizivele, inyibilika kancane emanzini, futhi inyibilika ezinhlobonhlobo zezincibilikisi eziphilayo. Iyisihluthulelo esimaphakathi ekuhlanganiseni izidakamizwa, isiza ekwakhiweni kwemithi elwa namagciwane kanye ne-antiviral, futhi isetshenziswa nasekulungiseleleni izibulala-zinambuzane ezintsha nezinto eziphilayo.

3. I-5-Amino-6-methylnicotinic acid ethyl ester, nesakhiwo sayo esikhethekile sokuphuma kwendandatho ye-pyridine, inokusebenza kabusha okucebile. Embonini yezemithi, iyisisekelo sokuhlanganiswa kwezidakamizwa ezikhethekile; emkhakheni wezinto zokwakha, yengeza umbala ezintweni ezibonakalayo ze-organic optical futhi isezingeni eliphezulu elithembekile eliphakathi nendawo.

I-molecular formula ye-1211538-09-8 yi-C9H10N2O4, futhi isisindo se-molecular 210.19. Kungase kube uketshezi oluphuzi olungenambala olukhanyayo noma oluqinile oluyikristalu, futhi lungasetshenziswa njengendawo ephilayo ephakathi nendawo yemithi, esetshenziswa kakhulu ocwaningweni lwaselabhorethri nezinqubo zokuthuthukiswa kanye nezinqubo zokukhiqiza amakhemikhali. Kungase kube uketshezi oluphuzi olungenambala olukhanyayo noma oluqinile oluyikristalu, futhi lungasetshenziswa njengendawo ephilayo ephakathi nendawo yemithi, esetshenziswa kakhulu ocwaningweni lwaselabhorethri nezinqubo zokuthuthukiswa kanye nezinqubo zokukhiqiza amakhemikhali.