I-Larotrectinib Intermediate

I-29274-22-4 iyinhlanganisela yezinto eziphilayo enenani elibalulekile lokusetshenziswa, futhi igama layo lekhemikhali limiswe okwesikhashana njengokuthi [igama lekhemikhali elisebenzayo]. Isakhiwo sayo samangqamuzana siqukethe inhlanganisela ethile yamaqembu asebenzayo. Lesi sakhiwo esiyingqayizivele siwunikeza umsebenzi okhethekile wamakhemikhali kanye nezakhiwo zomzimba. Ibonise amandla amakhulu ezimbonini eziningi, ikakhulukazi emkhakheni wamakhemikhali amahle kanye nokuguqulwa kwezinto ezibonakalayo, futhi ivame ukusetshenziswa njengendlela yokusabela okubalulekile okuphakathi.

I-29274-24-6 iyinhlanganisela enenani eliyingqayizivele embonini yamakhemikhali. Nakuba ulwazi lwayo lwangempela lungekho okwamanje, kusukela ekuhlaziyweni kwezakhiwo zamakhemikhali ezivamile, ingaba nokuhlelwa okukhethekile kwe-athomu kanye namaqembu asebenzayo, okukunikeza indima engenakuthathelwa indawo ekuphenduleni okuthile kwamakhemikhali futhi kulindeleke ukuthi ibe yingqikithi yezinto ezibonakalayo zokulungiswa kwezinto ezisebenza kahle kakhulu kanye namakhemikhali anomphumela okhethekile.

Emkhakheni wamakhemikhali emithi, umkhiqizo ophakathi obalulekile udonse ukunaka okukhulu, okuyi-1218935-60-4, eyaziwa nangokuthi (R) -2-(2,5-difluorophenyl)pyrrolidine hydrochloride. Ukuvela kwalo mkhiqizo kunikeza izinto zokusetshenziswa ezibalulekile zokwenziwa kwemithi futhi kukhuthaza ukuthuthukiswa kwemboni yezemithi.

I-1363380-51-1 iyinhlanganisela eye yaheha ukunaka okukhulu embonini yamakhemikhali nezinkambu ezihlobene. Nakuba kukhona ukuntuleka kolwazi oluningiliziwe, kucatshangelwa emithethweni evamile yocwaningo lwamakhemikhali ukuthi ingase ibe nesakhiwo samangqamuzana esiyingqayizivele nomsebenzi okhethekile wamakhemikhali, futhi kungenzeka kakhulu ibe into eyinhloko ekuthuthukisweni kwezinto ezintsha, ama-catalysts asebenza kahle kakhulu namakhemikhali amasha, okubonisa amathemba okusebenza okubanzi ezimbonini eziningi.

I-1919868-77-1 iyinhlanganisela engaqondakali enenani elingaba khona emikhakheni eminingi. Nakuba ulwazi lulinganiselwe okwamanje, ngokwemithetho evamile yocwaningo lwamakhemikhali, kucatshangwa ukuthi lunokwakheka kwamakhemikhali okuhlukile futhi lungaba namaqembu asebenzayo akhethekile, alunikeza indima ebalulekile ekuphenduleni kwamakhemikhali okuthile. Kulindeleke ukuthi ibambe iqhaza elibalulekile emikhakheni yezinto zokwakha, amandla, imithi, njll., futhi ilethe amathuba okuqamba izinto ezintsha ezimbonini ezihlobene.