I-AZD-5305 Intermediate

1. I-molecular formula ye-1008138-73-5 yi-C9H12N2O2. Iyimpushana emhlophe kuya kokumhlophe. Njengengxenye ebalulekile ye-organic, inokubili imisebenzi yeqembu le-amino ne-ester futhi isetshenziswa kabanzi emkhakheni wezokwelapha, izibulala-zinambuzane kanye nesayensi yezinto. Inekhwalithi ethembekile nokuhlanzeka okuphezulu.

2. Ikhwalithi ephezulu ye-5-amino-6-methylnicotinate ethyl ester inezinto zamakhemikhali eziyingqayizivele, inyibilika kancane emanzini, futhi inyibilika ezinhlobonhlobo zezincibilikisi eziphilayo. Iyisihluthulelo esimaphakathi ekuhlanganiseni izidakamizwa, isiza ekwakhiweni kwemithi elwa namagciwane kanye ne-antiviral, futhi isetshenziswa nasekulungiseleleni izibulala-zinambuzane ezintsha nezinto eziphilayo.

3. I-5-Amino-6-methylnicotinic acid ethyl ester, nesakhiwo sayo esikhethekile sokuphuma kwendandatho ye-pyridine, inokusebenza kabusha okucebile. Embonini yezemithi, iyisisekelo sokuhlanganiswa kwezidakamizwa ezikhethekile; emkhakheni wezinto zokwakha, yengeza umbala ezintweni ezibonakalayo ze-organic optical futhi isezingeni eliphezulu elithembekile eliphakathi nendawo.

I-molecular formula ye-1211538-09-8 yi-C9H10N2O4, futhi isisindo se-molecular 210.19. Kungase kube uketshezi oluphuzi olungenambala olukhanyayo noma oluqinile oluyikristalu, futhi lungasetshenziswa njengendawo ephilayo ephakathi nendawo yemithi, esetshenziswa kakhulu ocwaningweni lwaselabhorethri nezinqubo zokuthuthukiswa kanye nezinqubo zokukhiqiza amakhemikhali. Kungase kube uketshezi oluphuzi olungenambala olukhanyayo noma oluqinile oluyikristalu, futhi lungasetshenziswa njengendawo ephilayo ephakathi nendawo yemithi, esetshenziswa kakhulu ocwaningweni lwaselabhorethri nezinqubo zokuthuthukiswa kanye nezinqubo zokukhiqiza amakhemikhali.